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Differential Expression of PU.1 and Key T Lineage Transcription Factors Distinguishes Fetal and Adult T Cell Development

The PU.1 transcription factor plays a critical role in the regulation of T cell development, so a report that it is dispensable for fetal thymopoiesis is puzzling. In order to understand this paradox, we examined the requirement for PU.1, encoded by Spi1, during fetal, neonatal, and adult thymopoies...

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Publicat a:J Immunol
Autors principals: Montecino-Rodriguez, Encarnacion, Casero, David, Fice, Michael, Le, Jonathan, Dorshkind, Kenneth
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840016/
https://ncbi.nlm.nih.gov/pubmed/29436414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701336
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