Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis

The paralogous Brr6 and Brl1 are conserved integral membrane proteins of the nuclear envelope (NE) with an unclear role in nuclear pore complex (NPC) biogenesis. Here, we analyzed double-degron mutants of Brr6/Brl1 to understand this function. Depletion of Brr6 and Brl1 caused defects in NPC biogene...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Zhang, Wanlu, Neuner, Annett, Rüthnick, Diana, Sachsenheimer, Timo, Lüchtenborg, Christian, Brügger, Britta, Schiebel, Elmar
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839787/
https://ncbi.nlm.nih.gov/pubmed/29439116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201706024
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