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Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism
Alzheimer’s disease (AD) is a neurodegenerative disease that causes late-onset dementia. The R47H variant of the microglial receptor TREM2 triples AD risk in genome-wide association studies. In mouse AD models, TREM2-deficient microglia fail to proliferate and cluster around the amyloid-β plaques ch...
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| Izdano u: | J Exp Med |
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| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5839761/ https://ncbi.nlm.nih.gov/pubmed/29321225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171529 |
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