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Ligand field molecular dynamics simulation of Pt(II)-phenanthroline binding to N-terminal fragment of amyloid-β peptide

We report microsecond timescale molecular dynamics simulation of the complex formed between Pt(II)-phenanthroline and the 16 N-terminal residues of the Aβ peptide that is implicated in the onset of Alzheimer’s disease, along with equivalent simulations of the metal-free peptide. Simulations from a v...

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Publicat a:PLoS One
Autors principals: Turner, Matthew, Mutter, Shaun T., Deeth, Robert J., Platts, James A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839559/
https://ncbi.nlm.nih.gov/pubmed/29509784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193668
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