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The combined force field-sampling problem in simulations of disordered amyloid-β peptides

Molecular dynamics simulations of intrinsically disordered proteins (IDPs) can provide high resolution structural ensembles if the force field is accurate enough and if the simulation sufficiently samples the conformational space of the IDP with the correct weighting of sub-populations. Here, we inv...

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Detalhes bibliográficos
Publicado no:J Chem Phys
Main Authors: Lincoff, James, Sasmal, Sukanya, Head-Gordon, Teresa
Formato: Artigo
Idioma:Inglês
Publicado em: AIP Publishing LLC 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417907/
https://ncbi.nlm.nih.gov/pubmed/30876367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.5078615
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