Potent anti-tumor activity of a syringolin analog in multiple myeloma: a dual inhibitor of proteasome activity targeting β2 and β5 subunits

Proteasome inhibitors (PI), mainly targeting the β5 subunit of the 20S proteasome, are widely used in the treatment of multiple myeloma (MM). However, PI resistance remains an unresolved problem in the therapy of relapsed and refractory MM. To develop a new PI that targets other proteasome subunits,...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Yoshida, Takashi, Ri, Masaki, Kanamori, Takashi, Aoki, Sho, Ashour, Reham, Kinoshita, Shiori, Narita, Tomoko, Totani, Haruhito, Masaki, Ayako, Ito, Asahi, Kusumoto, Shigeru, Ishida, Takashi, Komatsu, Hirokazu, Kitahata, Shun, Chiba, Takuya, Ichikawa, Satoshi, Iida, Shinsuke
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2018
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839415/
https://ncbi.nlm.nih.gov/pubmed/29515784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24160
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