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Control of hyperglycemia in male mice by leflunomide: Mechanisms of action
p70 S6 kinase (S6K1) is a serine/threonine kinase that phosphorylates the insulin receptor substrate-1 (IRS-1) at serine 1101 and desensitizes insulin receptor signaling. S6K1 hyper-activation due to overnutrition leads to hyperglycemia and type 2 diabetes. Our recent study showed that A77 1726, the...
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| Publicado no: | J Endocrinol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5839151/ https://ncbi.nlm.nih.gov/pubmed/29496905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-17-0536 |
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