The Sonic Hedgehog Signaling Pathway Maintains the Cancer Stem Cell Self-Renewal of Anaplastic Thyroid Cancer by Inducing Snail Expression

CONTEXT: Cancer stem cells (CSCs) have been recently identified in thyroid neoplasm. Anaplastic thyroid cancer (ATC) contains a higher percentage of CSCs than well-differentiated thyroid cancer. The signaling pathways and the transcription factors that regulate thyroid CSC self-renewal remain poorly...

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Publicado en:J Clin Endocrinol Metab
Main Authors: Heiden, Katherine B., Williamson, Ashley J., Doscas, Michelle E., Ye, Jin, Wang, Yimin, Liu, Dingxie, Xing, Mingzhao, Prinz, Richard A., Xu, Xiulong
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2014
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Hot Topics in Translational Endocrinology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393503/
https://ncbi.nlm.nih.gov/pubmed/25078145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-1844
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