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The Akt Inhibitor MK2206 Synergizes, but Perifosine Antagonizes, the BRAF(V600E) Inhibitor PLX4032 and the MEK1/2 Inhibitor AZD6244 in the Inhibition of Thyroid Cancer Cells
PURPOSE: The purpose of the study was to explore optimal combinations of currently actively developed drugs for dually targeting the Ras → Raf → MAPK kinase (MEK) → MAPK/ERK (MAPK) and the phosphatidylinositol 3-kinase/Akt pathways as effective treatments for thyroid cancer. EXPERIMENTAL DESIGN: We...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Endocrine Society
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3275354/ https://ncbi.nlm.nih.gov/pubmed/22090271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2011-1054 |
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