Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides

Exposure of the telomere overhang acts as a DNA damage signal, and exogenous administration of an 11-base oligonucleotide homologous to the 3′-telomere overhang sequence (T-oligo) mimics the effects of overhang exposure by inducing senescence and cell death in non-small cell lung cancer (NSCLC) cell...

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Publicado no:Cancer Lett
Main Authors: Puri, Neelu, Pitman, Ryan T., Mulnix, Richard E., Erickson, Terrianne, Iness, Audra N., Vitali, Connie, Zhao, Yutong, Salgia, Ravi
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839143/
https://ncbi.nlm.nih.gov/pubmed/24041868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.09.010
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