Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations

The sonic hedgehog (SHH) signaling pathway has been shown to play important roles in embryogenesis, cell proliferation as well as in cell differentiation. It is aberrantly activated in various common cancers in adults, but also in pediatric neoplasms, such as rhabdomyosarcoma (RMS) and atypical tera...

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Publicado en:Eur J Hum Genet
Autores principales: Taeubner, Julia, Brozou, Triantafyllia, Qin, Nan, Bartl, Jasmin, Ginzel, Sebastian, Schaper, Joerg, Felsberg, Joerg, Fulda, Simone, Vokuhl, Christian, Borkhardt, Arndt, Kuhlen, Michaela
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
Materias:
Brief Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839031/
https://ncbi.nlm.nih.gov/pubmed/29230040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-017-0048-4
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