Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations

The sonic hedgehog (SHH) signaling pathway has been shown to play important roles in embryogenesis, cell proliferation as well as in cell differentiation. It is aberrantly activated in various common cancers in adults, but also in pediatric neoplasms, such as rhabdomyosarcoma (RMS) and atypical tera...

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Bibliografski detalji
Izdano u:Eur J Hum Genet
Glavni autori: Taeubner, Julia, Brozou, Triantafyllia, Qin, Nan, Bartl, Jasmin, Ginzel, Sebastian, Schaper, Joerg, Felsberg, Joerg, Fulda, Simone, Vokuhl, Christian, Borkhardt, Arndt, Kuhlen, Michaela
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Brief Communication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839031/
https://ncbi.nlm.nih.gov/pubmed/29230040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-017-0048-4
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