RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs

BACKGROUND: There is a need for more powerful methods to identify low-effect SNPs that contribute to hereditary COPD pathogenesis. We hypothesized that SNPs contributing to COPD risk through cis-regulatory effects are enriched in genes comprised by bronchial epithelial cell (BEC) expression patterns...

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Detalhes bibliográficos
Publicado no:BMC Pulm Med
Main Authors: Yeo, Jiyoun, Morales, Diego A., Chen, Tian, Crawford, Erin L., Zhang, Xiaolu, Blomquist, Thomas M., Levin, Albert M., Massion, Pierre P., Arenberg, Douglas A., Midthun, David E., Mazzone, Peter J., Nathan, Steven D., Wainz, Ronald J., Nana-Sinkam, Patrick, Willey, Paige F. S., Arend, Taylor J., Padda, Karanbir, Qiu, Shuhao, Federov, Alexei, Hernandez, Dawn-Alita R., Hammersley, Jeffrey R., Yoon, Youngsook, Safi, Fadi, Khuder, Sadik A., Willey, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838965/
https://ncbi.nlm.nih.gov/pubmed/29506519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12890-018-0603-y
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