RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs

BACKGROUND: There is a need for more powerful methods to identify low-effect SNPs that contribute to hereditary COPD pathogenesis. We hypothesized that SNPs contributing to COPD risk through cis-regulatory effects are enriched in genes comprised by bronchial epithelial cell (BEC) expression patterns...

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Publicado en:BMC Pulm Med
Autores principales: Yeo, Jiyoun, Morales, Diego A., Chen, Tian, Crawford, Erin L., Zhang, Xiaolu, Blomquist, Thomas M., Levin, Albert M., Massion, Pierre P., Arenberg, Douglas A., Midthun, David E., Mazzone, Peter J., Nathan, Steven D., Wainz, Ronald J., Nana-Sinkam, Patrick, Willey, Paige F. S., Arend, Taylor J., Padda, Karanbir, Qiu, Shuhao, Federov, Alexei, Hernandez, Dawn-Alita R., Hammersley, Jeffrey R., Yoon, Youngsook, Safi, Fadi, Khuder, Sadik A., Willey, James C.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838965/
https://ncbi.nlm.nih.gov/pubmed/29506519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12890-018-0603-y
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