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Homologous recombination mediates stable Fah gene integration and phenotypic correction in tyrosinaemia mouse-model
AIM: To stably correct tyrosinaemia in proliferating livers of fumarylacetoacetate-hydrolase knockout (Fah(-/-)) mice by homologous-recombination-mediated targeted addition of the Fah gene. METHODS: C57BL/6 Fah(∆exon5) mice served as an animal model for human tyrosinaemia type 1 in our study. The ve...
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| Publicado no: | World J Hepatol |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Baishideng Publishing Group Inc
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5838446/ https://ncbi.nlm.nih.gov/pubmed/29527263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4254/wjh.v10.i2.277 |
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