Src Family Kinases Regulate Interferon Regulatory Factor 1 K63 Ubiquitination following Activation by TLR7/8 Vaccine Adjuvant in Human Monocytes and B Cells

Toll-like receptors (TLRs) play a key role in the activation of innate immune cells, in which their engagement leads to production of cytokines and co-stimulatory molecules. TLRs signaling requires recruitment of toll/IL-1R (TIR) domain-containing adaptors, such as MyD88 and/or TRIF, and leads to ac...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Tulli, Lorenza, Cattaneo, Francesca, Vinot, Juliette, Baldari, Cosima T., D’Oro, Ugo
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837968/
https://ncbi.nlm.nih.gov/pubmed/29545793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00330
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