Src Family Kinases Regulate Interferon Regulatory Factor 1 K63 Ubiquitination following Activation by TLR7/8 Vaccine Adjuvant in Human Monocytes and B Cells

Toll-like receptors (TLRs) play a key role in the activation of innate immune cells, in which their engagement leads to production of cytokines and co-stimulatory molecules. TLRs signaling requires recruitment of toll/IL-1R (TIR) domain-containing adaptors, such as MyD88 and/or TRIF, and leads to ac...

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Detalhes bibliográficos
Main Authors: Lorenza Tulli, Francesca Cattaneo, Juliette Vinot, Cosima T. Baldari, Ugo D’Oro
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-03-01
Colecção:Frontiers in Immunology
Assuntos:
toll-like receptor
innate immunity
interferon regulatory factor 1
ubiquitination
TNF receptor associated factor 6
Src family kinases
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00330/full
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