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Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody
In amyotrophic lateral sclerosis (ALS) and animal models of ALS, including SOD1-G93A mice, disassembly of the neuromuscular synapse precedes motor neuron loss and is sufficient to cause a decline in motor function that culminates in lethal respiratory paralysis. We treated SOD1-G93A mice with an ago...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5837562/ https://ncbi.nlm.nih.gov/pubmed/29460776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34375 |
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