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Muscle-specific kinase (MuSK) autoantibodies suppress the MuSK pathway and ACh receptor retention at the mouse neuromuscular junction

Muscle-specific kinase (MuSK) autoantibodies from myasthenia gravis patients can block the activation of MuSK in vitro and/or reduce the postsynaptic localization of MuSK. Here we use a mouse model to examine the effects of MuSK autoantibodies upon some key components of the postsynaptic MuSK pathwa...

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Publicat a:J Physiol
Autors principals: Ghazanfari, Nazanin, Morsch, Marco, Reddel, Stephen W, Liang, Simon X, Phillips, William D
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221826/
https://ncbi.nlm.nih.gov/pubmed/24860174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.270207
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