Adenoviral intramyocardial VEGF-D(ΔNΔC) gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up

AIMS: We evaluated for the first time the effects of angiogenic and lymphangiogenic AdVEGF-D(ΔNΔC) gene therapy in patients with refractory angina. METHODS AND RESULTS: Thirty patients were randomized to AdVEGF-D(ΔNΔC) (AdVEGF-D) or placebo (control) groups. Electromechanical NOGA mapping and radiow...

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Dettagli Bibliografici
Pubblicato in:Eur Heart J
Autori principali: Hartikainen, Juha, Hassinen, Iiro, Hedman, Antti, Kivelä, Antti, Saraste, Antti, Knuuti, Juhani, Husso, Minna, Mussalo, Hanna, Hedman, Marja, Rissanen, Tuomas T., Toivanen, Pyry, Heikura, Tommi, Witztum, Joseph L., Tsimikas, Sotirios, Ylä-Herttuala, Seppo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Clinical Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837555/
https://ncbi.nlm.nih.gov/pubmed/28903476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehx352
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