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Antiangiogenic Gene Therapy With Soluble VEGFR-1, -2, and -3 Reduces the Growth of Solid Human Ovarian Carcinoma in Mice

We studied antiangiogenic and antilymphangiogenic effects of sVEGFR-1 (sFlt-1), sVEGFR-2 (sFlk-1/KDR), and sVEGFR-3 (sFlt-4) gene transfers and their combinations in intraperitoneal ovarian cancer xenograft mice (Balb/c-Anu, n = 55). Gene therapy was initiated when the presence of sizable tumors was...

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Detalhes bibliográficos
Main Authors: Sallinen, Hanna, Anttila, Maarit, Narvainen, Johanna, Koponen, Jonna, Hamalainen, Kirsi, Kholova, Ivana, Heikura, Tommi, Toivanen, Pyry, Kosma, Veli-Matti, Heinonen, Seppo, Alitalo, Kari, Yla-Herttuala, Seppo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835051/
https://ncbi.nlm.nih.gov/pubmed/19050699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.258
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