Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants

Prolonged hyperoxia contributes to bronchopulmonary dysplasia (BPD) in preterm infants. β-Naphthoflavone (BNF) is a potent inducer of cytochrome P450 (CYP)1A enzymes, which have been implicated in hyperoxic injuries in adult mice. In this investigation, we tested the hypothesis that newborn mice lac...

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發表在:Toxicol Sci
Main Authors: Maturu, Paramahamsa, Wei-Liang, Yanhong, Jiang, Weiwu, Wang, Lihua, Lingappan, Krithika, Barrios, Roberto, Liang, Yao, Moorthy, Bhagavatula, Couroucli, Xanthi I.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2017
主題:
Cyp1a1 and Oxygen-Mediated Lung Injury
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837454/
https://ncbi.nlm.nih.gov/pubmed/28201809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx036
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