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Net Reclassification Index and Integrated Discrimination Index Are Not Appropriate for Testing Whether a Biomarker Improves Predictive Performance

One of the goals of the Critical Path Institute’s Predictive Safety Testing Consortium (PSTC) is to promote best practices for evaluating novel markers of drug induced injury. This includes the use of sound statistical methods. For rat studies, these practices have centered around comparing the area...

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Bibliografische gegevens
Gepubliceerd in:Toxicol Sci
Hoofdauteurs: Burch, Peter M., Glaab, Warren E., Holder, Daniel J., Phillips, Jonathan A., Sauer, John-Michael, Walker, Elizabeth G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837334/
https://ncbi.nlm.nih.gov/pubmed/27815493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw225
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