Effect of Sorbitol on the Pharmacokinetic Profile of Lamivudine Oral Solution in Adults: An Open‐Label, Randomized Study

In children aged ≤4 years, the relative bioavailability of lamivudine oral solution was 37% lower than that of a tablet formulation. An open‐label, four‐way crossover study was conducted in healthy adults to evaluate the effect of sorbitol, a common liquid excipient, on the pharmacokinetics of lamiv...

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Vydáno v:Clin Pharmacol Ther
Hlavní autoři: Adkison, Kimberly, Wolstenholme, Allen, Lou, Yu, Zhang, Zhiping, Eld, Amy, Perger, Teodora, Vangerow, Harald, Hayward, Katy, Shaefer, Mark, McCoig, Cynthia
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Clinical Trial
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836851/
https://ncbi.nlm.nih.gov/pubmed/29150845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.943
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