Colon-targeted delivery of cyclosporine A using dual-functional Eudragit(®) FS30D/PLGA nanoparticles ameliorates murine experimental colitis

BACKGROUND: Colon-targeted oral nanoparticles (NPs) have emerged as an ideal, safe, and effective therapy for ulcerative colitis (UC) owing to their ability to selectively accumulate in inflamed colonic mucosa. Cyclosporine A (CSA), an immunosuppressive agent, has long been used as rescue therapy in...

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Vydáno v:Int J Nanomedicine
Hlavní autoři: Naeem, Muhammad, Bae, Junhwan, Oshi, Murtada A, Kim, Min-Soo, Moon, Hyung Ryong, Lee, Bok Luel, Im, Eunok, Jung, Yunjin, Yoo, Jin-Wook
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2018
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836652/
https://ncbi.nlm.nih.gov/pubmed/29535519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S157566
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