AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity

BACKGROUND: In mammals, the AKT/PKB protein kinase family comprises three members (AKT1–3). PI3-Kinase (PI3K), a key oncogene involved in a wide variety of cancers, drives AKT activity. Constitutive activation of the PI3K/AKT pathway has been associated with tumorigenic properties including uncontro...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Brolih, Sanja, Parks, Scott K., Vial, Valérie, Durivault, Jérôme, Mostosi, Livio, Pouysségur, Jacques, Pagès, Gilles, Picco, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836445/
https://ncbi.nlm.nih.gov/pubmed/29506489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4169-0
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