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Phosphorylation-mediated structural changes within the SOAR domain of stromal interaction molecule 1 enable specific activation of distinct Orai channels

Low-conductance, highly calcium-selective channels formed by the Orai proteins exist as store-operated CRAC channels and store-independent, arachidonic acid–activated ARC channels. Both are activated by stromal interaction molecule 1 (STIM1), but CRAC channels are activated by STIM1 located in the e...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Thompson, Jill L., Zhao, Yue, Stathopulos, Peter B., Grossfield, Alan, Shuttleworth, Trevor J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836120/
https://ncbi.nlm.nih.gov/pubmed/29326165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.819078
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