Knockout of the placenta specific 8 gene radiosensitizes nasopharyngeal carcinoma cells by activating the PI3K/AKT/GSK3β pathway

The present study investigated the radiosensitizing effect of placenta specific 8 (PLAC8) in nasopharyngeal carcinoma (NPC) cells. A PLAC8-knockout CNE2 cell line was constructed using the CRISPR/Cas9 system. The CCK-8 assay demonstrated knockout of PLAC8 significantly reduced cell proliferation and...

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Bibliografiske detaljer
Udgivet i:Am J Transl Res
Main Authors: Yang, Rui, Tao, Ze-Zhang, Huang, Mao-Ling, Zheng, Yong-Fa, Dai, Meng-Yuan, Zou, You, Chen, Shi-Ming
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2018
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835810/
https://ncbi.nlm.nih.gov/pubmed/29511439
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