Tamoxifen enhances stemness and promotes metastasis of ERα36(+) breast cancer by upregulating ALDH1A1 in cancer cells

The 66 kDa estrogen receptor alpha (ERα66) is the main molecular target for endocrine therapy such as tamoxifen treatment. However, many patients develop resistance with unclear mechanisms. In a large cohort study of breast cancer patients who underwent surgery followed by tamoxifen treatment, we de...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Wang, Qiang, Jiang, Jun, Ying, Guoguang, Xie, Xiao-Qing, Zhang, Xia, Xu, Wei, Zhang, Xuemin, Song, Erwei, Bu, Hong, Ping, Yi-Fang, Yao, Xiao-Hong, Wang, Bin, Xu, Shilei, Yan, Ze-Xuan, Tai, Yanhong, Hu, Baoquan, Qi, Xiaowei, Wang, Yan-Xia, He, Zhi-Cheng, Wang, Yan, Wang, Ji Ming, Cui, You-Hong, Chen, Feng, Meng, Kun, Wang, Zhaoyi, Bian, Xiu-Wu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835774/
https://ncbi.nlm.nih.gov/pubmed/29393296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2018.15
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