The effect of xanthine oxidase and hypoxanthine on the permeability of red cells from patients with sickle cell anemia

Red cells from patients with sickle cell anemia (SCA) are under greater oxidative challenge than those from normal individuals. We postulated that oxidants generated by xanthine oxidase (XO) and hypoxanthine (HO) contribute to the pathogenesis of SCA through altering solute permeability. Sickling, a...

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Dades bibliogràfiques
Publicat a:Physiol Rep
Autors principals: Al Balushi, Halima W. M., Rees, David C., Brewin, John N., Hannemann, Anke, Gibson, John S.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835498/
https://ncbi.nlm.nih.gov/pubmed/29504282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13626
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