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The effect of xanthine oxidase and hypoxanthine on the permeability of red cells from patients with sickle cell anemia

Red cells from patients with sickle cell anemia (SCA) are under greater oxidative challenge than those from normal individuals. We postulated that oxidants generated by xanthine oxidase (XO) and hypoxanthine (HO) contribute to the pathogenesis of SCA through altering solute permeability. Sickling, a...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Al Balushi, Halima W. M., Rees, David C., Brewin, John N., Hannemann, Anke, Gibson, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835498/
https://ncbi.nlm.nih.gov/pubmed/29504282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13626
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