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Functional characterization of the G162R and D216H genetic variants of human CYP17A1
Cytochrome P450 17A1 (CYP17A1) is a dual-function enzyme catalyzing reactions necessary for cortisol and androgen biosynthesis. CYP17A1 is a validated drug target for prostate cancer as CYP17A1 inhibition significantly reduces circulating androgens and improves survival in castration-resistant prost...
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| Publicado no: | J Steroid Biochem Mol Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5835412/ https://ncbi.nlm.nih.gov/pubmed/29229304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2017.12.002 |
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