Vascular Endothelial Cell-Specific Connective Tissue Growth Factor (CTGF) Is Necessary for Development of Chronic Hypoxia-Induced Pulmonary Hypertension

Chronic hypoxia frequently complicates the care of patients with interstitial lung disease, contributing to the development of pulmonary hypertension (PH), and premature death. Connective tissue growth factor (CTGF), a matricellular protein of the Cyr61/CTGF/Nov (CCN) family, is known to exacerbate...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Pi, Liya, Fu, Chunhua, Lu, Yuanquing, Zhou, Junmei, Jorgensen, Marda, Shenoy, Vinayak, Lipson, Kenneth E., Scott, Edward W., Bryant, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835098/
https://ncbi.nlm.nih.gov/pubmed/29535639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00138
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