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Vascular Endothelial Cell-Specific Connective Tissue Growth Factor (CTGF) Is Necessary for Development of Chronic Hypoxia-Induced Pulmonary Hypertension

Chronic hypoxia frequently complicates the care of patients with interstitial lung disease, contributing to the development of pulmonary hypertension (PH), and premature death. Connective tissue growth factor (CTGF), a matricellular protein of the Cyr61/CTGF/Nov (CCN) family, is known to exacerbate...

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Publicat a:Front Physiol
Autors principals: Pi, Liya, Fu, Chunhua, Lu, Yuanquing, Zhou, Junmei, Jorgensen, Marda, Shenoy, Vinayak, Lipson, Kenneth E., Scott, Edward W., Bryant, Andrew J.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835098/
https://ncbi.nlm.nih.gov/pubmed/29535639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00138
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