mRNA Vaccine with Antigen-Specific Checkpoint Blockade Induces an Enhanced Immune Response against Established Melanoma

We reported a preclinical cancer vaccine that simultaneously introduced an mRNA antigen and an immune checkpoint blocking siRNA into the antigen-presenting cells. This was achieved by formulating both nucleic acid-based immunotherapeutics into a lipid-coated calcium phosphate (LCP) nanoparticle (NP)...

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Vydáno v:Mol Ther
Hlavní autoři: Wang, Yuhua, Zhang, Lu, Xu, Zhenghong, Miao, Lei, Huang, Leaf
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2018
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835019/
https://ncbi.nlm.nih.gov/pubmed/29249397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.11.009
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