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CRISPR approaches to small molecule target identification

A long-standing challenge in drug development is the identification of the mechanisms of action of small molecules with therapeutic potential. A number of methods have been developed to address this challenge, each with inherent strengths and limitations. We here provide a brief review of these meth...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Jost, Marco, Weissman, Jonathan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834945/
https://ncbi.nlm.nih.gov/pubmed/29261286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00965
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