Hepatocyte specific expression of an oncogenic variant of β-catenin results in lethal metabolic dysfunction in mice

BACKGROUND: Wnt/β-catenin signaling plays a crucial role in embryogenesis, tissue homeostasis, metabolism and malignant transformation of different organs including the liver. Continuous β-catenin signaling due to somatic mutations in exon 3 of the Ctnnb1 gene is associated with different liver dise...

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Vydáno v:Oncotarget
Hlavní autoři: Lemberger, Ursula J., Fuchs, Claudia D., Schöfer, Christian, Bileck, Andrea, Gerner, Christopher, Stojakovic, Tatjana, Taketo, Makoto M., Trauner, Michael, Egger, Gerda, Österreicher, Christoph H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834276/
https://ncbi.nlm.nih.gov/pubmed/29541410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24346
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