Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disorder in which genetic and environmental factors synergistically lead to loss of midbrain dopamine (DA) neurons. Mutation of leucine-rich repeated kinase2 (Lrrk2) genes is responsible for the majority of inherited familial cases of PD and can also b...

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Udgivet i:Cell Death Dis
Main Authors: Tozzi, Alessandro, Tantucci, Michela, Marchi, Saverio, Mazzocchetti, Petra, Morari, Michele, Pinton, Paolo, Mancini, Andrea, Calabresi, Paolo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833812/
https://ncbi.nlm.nih.gov/pubmed/29434188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0221-2
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