Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas: A Phase 2 Clinical Trial

IMPORTANCE: There is a strong rationale for treating sarcomas with immunotherapy. OBJECTIVE: To assess the efficacy and safety of programmed cell death protein 1 (PD-1) targeting in combination with metronomic chemotherapy in sarcomas. DESIGN, SETTING, AND PARTICIPANTS: This was an open-label, multi...

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Bibliografische gegevens
Gepubliceerd in:JAMA Oncol
Hoofdauteurs: Toulmonde, Maud, Penel, Nicolas, Adam, Julien, Chevreau, Christine, Blay, Jean-Yves, Le Cesne, Axel, Bompas, Emmanuelle, Piperno-Neumann, Sophie, Cousin, Sophie, Grellety, Thomas, Ryckewaert, Thomas, Bessede, Alban, Ghiringhelli, François, Pulido, Marina, Italiano, Antoine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Medical Association 2017
Onderwerpen:
Brief Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833654/
https://ncbi.nlm.nih.gov/pubmed/28662235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2017.1617
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