Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111

Amyotrophic lateral sclerosis (ALS) involves the abnormal posttranslational modifications and fibrillization of copper, zinc superoxide dismutase (SOD1) and TDP-43. However, how SOD1-catalyzed reaction product hydrogen peroxide affects amyloid formation of SOD1 and TDP-43 remains elusory. 90% of ALS...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Xu, Wen-Chang, Liang, Jin-Zhao, Li, Cheng, He, Zhi-Xin, Yuan, Han-Ye, Huang, Ben-Yan, Liu, Xiao-Ling, Tang, Bo, Pang, Dai-Wen, Du, Hai-Ning, Yang, Yi, Chen, Jie, Wang, Lei, Zhang, Min, Liang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833406/
https://ncbi.nlm.nih.gov/pubmed/29358575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0106-4
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