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Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry
Although drug development typically focuses on binding thermodynamics, recent studies suggest that kinetic properties can strongly impact a drug candidate’s efficacy. Robust techniques for measuring inhibitor association and dissociation rates are therefore essential. To address this need, we have d...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5832847/ https://ncbi.nlm.nih.gov/pubmed/29497037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03263-3 |
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