Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice

Activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) has been implicated in diverse kidney diseases, yet its in vivo significance in diabetic nephropathy (DN) is largely unknown. In the present study, we demonstrated a podocyte-specific Rac1-deficient mouse strain and showed that specific...

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Bibliografiset tiedot
Julkaisussa:Cell Death Dis
Päätekijät: Lv, Zhimei, Hu, Mengsi, Fan, Minghua, Li, Xiaobing, Lin, Jiangong, Zhen, Junhui, Wang, Ziyang, Jin, Haijun, Wang, Rong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832796/
https://ncbi.nlm.nih.gov/pubmed/29497040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0353-z
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