Sei-1 promotes double minute chromosomes formation through activation of the PI3K/Akt/BRCA1-Abraxas pathway and induces double-strand breaks in NIH-3T3 fibroblasts

Sei-1 is a potential oncogene that plays an important role in promoting genomic instability. Double minute chromosomes (DMs) are hallmarks of gene amplification and contribute to tumorigenesis. Defects in the DNA double-strand break (DSB) repairing pathways can lead to gene amplification. To date, t...

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Publicado no:Cell Death Dis
Main Authors: Tian, Xing, Liu, Chang, Wang, Xin, Wang, Fei, Wang, Liqun, Xu, Lu, Ma, Jinfa, Gao, Yating, Bao, Yantao, Wang, Falin, Sun, Luyao, Wei, Junni, Lin, Chuwen, Zhang, He, Zhu, Gang, Guan, Xinyuan, Fu, Songbin, Zhang, Chunyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832785/
https://ncbi.nlm.nih.gov/pubmed/29497033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0362-y
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