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Hypoxia enhances H(2)O(2)-mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation

The exact regulation of the liver-secreted peptide hepcidin, the key regulator of systemic iron homeostasis, is still poorly understood. It is potently induced by iron, inflammation, cytokines or H(2)O(2) but conflicting results have been reported on hypoxia. In our current study, we first show that...

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Bibliografski detalji
Izdano u:Redox Biol
Glavni autori: Silva, Inês, Rausch, Vanessa, Peccerella, Teresa, Millonig, Gunda, Seitz, Helmut-Karl, Mueller, Sebastian
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832675/
https://ncbi.nlm.nih.gov/pubmed/29459227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.02.005
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