Sustained Submicromolar H(2)O(2) Levels Induce Hepcidin via Signal Transducer and Activator of Transcription 3 (STAT3)

The peptide hormone hepcidin regulates mammalian iron homeostasis by blocking ferroportin-mediated iron export from macrophages and the duodenum. During inflammation, hepcidin is strongly induced by interleukin 6, eventually leading to the anemia of chronic disease. Here we show that hepatoma cells...

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Detalhes bibliográficos
Main Authors: Millonig, Gunda, Ganzleben, Ingo, Peccerella, Teresa, Casanovas, Guillem, Brodziak-Jarosz, Lidia, Breitkopf-Heinlein, Katja, Dick, Tobias P., Seitz, Helmut-Karl, Muckenthaler, Martina U., Mueller, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481342/
https://ncbi.nlm.nih.gov/pubmed/22932892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.358911
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