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Statistical power and utility of meta-analysis methods for cross-phenotype genome-wide association studies

Advances in recent genome wide association studies (GWAS) suggest that pleiotropic effects on human complex traits are widespread. A number of classic and recent meta-analysis methods have been used to identify genetic loci with pleiotropic effects, but the overall performance of these methods is no...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhu, Zhaozhong, Anttila, Verneri, Smoller, Jordan W., Lee, Phil H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832233/
https://ncbi.nlm.nih.gov/pubmed/29494641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193256
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