PKM2 Is Required to Activate Myeloid Dendritic Cells from Patients with Severe Aplastic Anemia

Severe aplastic anemia (SAA) is an autoimmune disease in which bone marrow failure is mediated by activated myeloid dendritic cells (mDCs) and T lymphocytes. Recent research has identified a strong immunomodulatory effect of pyruvate kinase M2 (PKM2) on dendritic cells in immune-mediated diseases. I...

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Udgivet i:Oxid Med Cell Longev
Main Authors: Liu, Chunyan, Zheng, Mengying, Wang, Ting, Jiang, Huijuan, Fu, Rong, Wang, Huaquan, Ding, Kai, Zhou, Qiufan, Shao, Zonghong
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832124/
https://ncbi.nlm.nih.gov/pubmed/29636835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/1364165
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