PKM2 Is Required to Activate Myeloid Dendritic Cells from Patients with Severe Aplastic Anemia

Severe aplastic anemia (SAA) is an autoimmune disease in which bone marrow failure is mediated by activated myeloid dendritic cells (mDCs) and T lymphocytes. Recent research has identified a strong immunomodulatory effect of pyruvate kinase M2 (PKM2) on dendritic cells in immune-mediated diseases. I...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Liu, Chunyan, Zheng, Mengying, Wang, Ting, Jiang, Huijuan, Fu, Rong, Wang, Huaquan, Ding, Kai, Zhou, Qiufan, Shao, Zonghong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832124/
https://ncbi.nlm.nih.gov/pubmed/29636835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/1364165
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