PKM2 Is Required to Activate Myeloid Dendritic Cells from Patients with Severe Aplastic Anemia

Severe aplastic anemia (SAA) is an autoimmune disease in which bone marrow failure is mediated by activated myeloid dendritic cells (mDCs) and T lymphocytes. Recent research has identified a strong immunomodulatory effect of pyruvate kinase M2 (PKM2) on dendritic cells in immune-mediated diseases. I...

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Gepubliceerd in:Oxid Med Cell Longev
Hoofdauteurs: Liu, Chunyan, Zheng, Mengying, Wang, Ting, Jiang, Huijuan, Fu, Rong, Wang, Huaquan, Ding, Kai, Zhou, Qiufan, Shao, Zonghong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Hindawi 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832124/
https://ncbi.nlm.nih.gov/pubmed/29636835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/1364165
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