PKM2 Is Required to Activate Myeloid Dendritic Cells from Patients with Severe Aplastic Anemia

Severe aplastic anemia (SAA) is an autoimmune disease in which bone marrow failure is mediated by activated myeloid dendritic cells (mDCs) and T lymphocytes. Recent research has identified a strong immunomodulatory effect of pyruvate kinase M2 (PKM2) on dendritic cells in immune-mediated diseases. I...

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Vydáno v:Oxid Med Cell Longev
Hlavní autoři: Liu, Chunyan, Zheng, Mengying, Wang, Ting, Jiang, Huijuan, Fu, Rong, Wang, Huaquan, Ding, Kai, Zhou, Qiufan, Shao, Zonghong
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832124/
https://ncbi.nlm.nih.gov/pubmed/29636835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/1364165
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