Ephrin-B2 Prevents N-Methyl-D-Aspartate Receptor Antibody Effects on Memory and Neuroplasticity

OBJECTIVE: To demonstrate that ephrin-B2 (the ligand of EphB2 receptor) antagonizes the pathogenic effects of patients’ N-methyl-D-aspartate receptor (NMDAR) antibodies on memory and synaptic plasticity. METHODS: One hundred twenty-two C57BL/6J mice infused with cerebrospinal fluid (CSF) from patien...

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Published in:Ann Neurol
Main Authors: Planagumà, Jesús, Haselmann, Holger, Mannara, Francesco, Petit-Pedrol, Mar, Grünewald, Benedikt, Aguilar, Esther, Röpke, Luise, Martín-García, Elena, Titulaer, Maarten J., Jercog, Pablo, Graus, Francesc, Maldonado, Rafael, Geis, Christian, Dalmau, Josep
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832041/
https://ncbi.nlm.nih.gov/pubmed/27399303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24721
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