A Novel Mechanism of Mesenchymal Stromal Cell-Mediated Protection against Sepsis: Restricting Inflammasome Activation in Macrophages by Increasing Mitophagy and Decreasing Mitochondrial ROS

Sepsis, a systemic inflammatory response to infection, is the leading cause of death in the intensive care unit (ICU). Previous studies indicated that mesenchymal stromal cells (MSCs) might have therapeutic potential against sepsis. The current study was designed to investigate the effects of MSCs o...

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Publicado en:Oxid Med Cell Longev
Autores principales: Li, Shuang, Wu, Hao, Han, Dong, Ma, Sai, Fan, Wensi, Wang, Yabin, Zhang, Ran, Fan, Miaomiao, Huang, Yuesheng, Fu, Xiaobing, Cao, Feng
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831900/
https://ncbi.nlm.nih.gov/pubmed/29636842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/3537609
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